COX-2 expression and CGRP release in primary trigeminal ganglion neurons – implications for the pathophysiology of migraine

Trigeminal neurons are crucial for the pathophysiology of headache. In vivo, a host of stimuli leads to the release of neuropeptides e.g. calcitonine related peptide (CGRP). CGRP is known to play a crucial role in migraine pathophysiology and the transmission of pain. Serotonin receptor (5 HT1B/D) agonists, so called triptans, are able to cause significant pain relief in migraine attacks by blocking CGRP release. In addition, selective and non-selective cyclooxygenase (COX) inhibitors, so called non steroidal anti-inflammatory drugs, abort migraine attacks. Although NSAIDS are widely used for the treatment of he…