Tongue force variability in asymptomatic carriers of the Huntington gene – a biomarker for presymptomatic clinical studies?
S. Bohlen, F. Kirsten, H. Lohmann, D. Bracht, R. Bachmann, M. Weckesser, H.W. Lange, E.B. Ringelstein, R. Reilmann · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Isometric tongue force variability (TFV) assessed by measuring tongue protrusion forces (=glossomotography, see figure) was shown to be increased in patients with Huntington's Disease (HD) compared to controls. TFV also correlates with the severity of HD as assessed in the UHDRS motor score and the CAG-repeat length when normalized for age (Reilmann et al. 2003). Objective: To investigate whether TFV assessed in an isometric tongue protrusion task is pathologically increased in clinically asymptomatic carriers of the Huntington gene. Subjects and methods: HD gene carriers (n=13) and age-and-sex-matched hea…
