Characterisation of a conditional mouse-model of Parkinson's disease
S. Nuber, E. Petrasch-Parwez, T. Schmidt, H. Habbes, M. Löbbecke-Schumacher, P. Teismann, J.B. Schulz, M. Neumann, M. Fendt, B. Pichler, H. Nguyen, D. Berg, C. Holzmann, J. Boy, M. Kuhn, S. von Hörsten, I. Schmitt, A. Bornemann, F. Zimmermann, W. Kuhn, S.B. P… · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
alpha-Synuclein has been implicated in the pathophysiology of many neurodegenerative disorders, including Parkinson's disease (PD). In order to elucidate the role of this protein in the pathogenesis of PD, transgenic mice were created by using the tet-regulatable system driving the expression of human wildtype and mutated [A30P] alpha-synuclein in CNS neurons. Our studies demonstrate that the expression pattern depends on both the neuron-specific promoter and the integration site of the transgene constructs. Mice expressing high levels of human wildtype alpha-synuclein developed neuropathology and progressive mo…
