Clinical Trial: Efficacy and Tolerability of Entacapone versus Cabergoline in Elderly Parkinsonian Patients with Fluctuations

for the CAMP Study Group Objective: To investigate benefits and drawbacks of entacapone (ENT) and cabergoline (CBG) as adjuncts to Levodopa (LD) in elderly patients (pts) with Parkinson's disease (PD) suffering from wearing-off. Aims: Long-term LD therapy is associated with the emergence of motor complications, such as fluctuations and dyskinesias. The guidelines of the German Society of Neurology for the treatment of Parkinson's disease recommend dopamine agonists or COMT inhibitors. So far, there have been no comparisons between the COMT inhibitor entacapone and dopamine agonists at this stage of the disease.…