The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme

Genetic polymorphisms of methionine metabolism, in particular methionine synthase (MTR) c.2756A>G (D919G) and methylenetetrahydrofolate reductase (MTHFR) c.677C>T (A222V), have been associated with various human cancers. We investigated MTR c.2756A>G, MTHFR c.677C>T, and a third polymorphism, transcobalamin 2 (Tc2) c.776C>G (P259R), for a potential association with the formation of glioblastoma multiforme (GBM). The MTR c.2756G allele was significantly underrepresented among 213 GBM patients of Caucasian origin when compared to 400 population controls (Patients AA/AG/GG: 0.72/0.25/0.03 and controls AA/AG/GG: 0.5…