Assessment of nigrostriatal damage in schizophrenia using transcranial sonography and dopamin transporter imaging
L. Niehaus, K. Boelmanns, B. Schott, M. Glaser, C. Winter, R. Steinke · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
There are a some histopathological studies indicating nigrostriatal degeneration in patients with chronic schizophrenia. However, premortem differentiation between neuroleptic-induced parkinsonism and dopmaninergic nigrostriatal impairment in idiopathic Parkinson's disease (IPD) has been difficult. We report a 63 year old patient with chronic schizophrenia who had developed a slowly progressive hypokinetic-rigid syndrome under neuroleptic medication over 15 years. To evaluate the nigrostriatal dopaminergic innervation transcranial brain parenchyma sonography (TCS) and dopamine transporter (DAT) imaging using I-1…