Significant correlation between maternal body mass index at delivery and second trimester circulating total cell-free DNA levels
O Lapaire, T Volgmann, I Hoesli, S Grill, R Zanetti-Daellenbach, XY Zhong, W Holzgreve · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Objectives: The ability to reliably identify and quantify cell-free fetal (cff) DNA in maternal circulation has substantially increased the clinical application of noninvasive prenatal diagnosis. However, the clinical use of cff DNA and its interpretation requires the knowledge of important clinical variables. We hypothesized that cff and total cell-free DNA in maternal plasma may be correlated with maternal body mass index (BMI) and its change during pregnancy. Material and methods: In this study, using four hundred and six maternal blood samples from the second trimester of pregnancy, circulating fetal DNA in…
