CareLit Fachartikel

Expression of VEGFR and PDGFR in ovarian cancer tissue in the era of tryosine kinase inhibitors (TKI)

DO Bauerschlag, D Schaaf, C Schem, I Meinhold-Heerlein, W Jonat, N Maass · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1134669
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
DO Bauerschlag, D Schaaf, C Schem, I Meinhold-Heerlein, W Jonat, N Maass
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088688

Zusammenfassung

Aims: TKI are newly emerging drugs rushing into daily clinical use. Vascular endothelial growth factor receptor (VEGFR) and platelet derived growth factor (PDGFR) are prevalent targets of small molecules which precisely block TKI activation. In ovarian cancer the expression levels of these receptors could be indicative for the use of TKI. Material and Method: 98 ovarian cancer tissues were arranged in a tissue micro array and stained with monoclonal antibodies directed against VEGF-R1,-R2 and PDGFR-α and -β. Protein expression levels were scored using an IRS scoring system. Expression levels were correlated to t…

Schlagworte

PDGFR VEFGR immuhistochemistry ovarian cancer tyrosine kinase Tumor Biological Factors Antibodies Geburtshilfe und Frauenheilkunde