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Gene expression of topoisomerase II alpha by microarray analysis is highly prognostic in estrogen receptor (ER)+ breast cancer – prognostic value of Topoisomerase II alpha

A Rody, T Karn, E Ruckhaeberle, V Mueller, R Gaetje, U Holtrich, M Kaufmann · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1134670
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
A Rody, T Karn, E Ruckhaeberle, V Mueller, R Gaetje, U Holtrich, M Kaufmann
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088698

Zusammenfassung

Introduction Overexpression of Topoisomerase II alpha (TOP2A) has been implicated with gene amplification of the 17q21 amplicon and consecutively with ErbB2 overexpression/ amplification. However, gene amplification is not necessarily a prerequisite for gene expression per se. Methods Large scale analysis was performed using Affymetrix microarray data from n=1681 breast cancer patients to evaluate TOP2A expression. Results TOP2A expression showed a strong correlation with tumor size (Χ2-test, p

Schlagworte

Topoisomerase breast cancer microarray analysis prognosis Breast Tumor Geburtshilfe und Frauenheilkunde