CareLit Fachartikel

Gene expression changes triggered by adiponectin in human mammary epithelial and breast cancer cells

CR Lattrich, I Juhasz-Boess, F Horn, O Ortmann, O Treeck · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1134683
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
CR Lattrich, I Juhasz-Boess, F Horn, O Ortmann, O Treeck
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088828

Zusammenfassung

Serum levels of adiponectin are inversely associated with breast cancer risk. Adiponectin is reported to exert direct antitumoral effects by inhibition of cell proliferation and increase of apoptosis of breast cancer cells. We examined molecular mechanisms underlying the antitumoral action of adiponectin. For this purpose, we studied the effect of adiponectin on gene expression in a breast cancer cell line and a non-tumorigenic human mammary epithelial cell line. MCF–7 breast cancer cells and MCF–10A immortalized mammary epithelial cells were treated with adiponectin (10µg/ml) for 48h. Adiponectin effect on gene…

Schlagworte

adiponectin breast cancer cell lines estrogen receptor gene regulation Breast Caspase 1 Apoptosis Affect Geburtshilfe und Frauenheilkunde