Gene expression relations reveal tumour specific patterns

Objective: Often not single but multiple genes are indicative for a certain cancer diseases. Various multi-genes are under review of their validity in making a decision for effective treatment, like the increased expression of Aurora kinases in many solid cancers. In this study we take their relative expression to other genes as an additional dimension of relative expression into account. CDK2, Repp86, Aurora-kinase-A and -B are involved in the development of spindles, segregation of chromosomes and in the control of the mitotic cell division. Methods: We compared the gene expressions related to Repp86 in 11 nor…