CareLit Fachartikel

sCD44v6 is not a prognostic marker in patients with primary breast cancer

S Mayer, A zur Hausen, DO Watermann, C Gebhardt, G Gitsch, E Stickeler · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1134699
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
S Mayer, A zur Hausen, DO Watermann, C Gebhardt, G Gitsch, E Stickeler
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088988

Zusammenfassung

Purpose: CD44 is a cell surface glycoprotein involved in cell-cell and cell-substrate interactions, which may be shed or released into circulation. Alternative splicing of CD44 and aberrant levels of soluble CD44 variants in the serum of cancer patients have been correlated to tumor progression and metastasis in different tumors including breast cancer. In this study we evaluated the clinical value of CD44 serum levels (sCD44) in patients with primary breast cancer. Methods: Concentrations of soluble isoforms sCD44std, sCD44v5 and sCD44v6 were determined with a sensitive ELISA and normalized against the total pr…

Schlagworte

breast cancer lymph node metastasis soluble CD44 Breast Tumor Alternative Splicing Blood Donors Blood After Geburtshilfe und Frauenheilkunde