Neutrophil gelatinase-associated lipocalin (NGAL) is a prognostic marker in human primary breast cancer
M Bauer, J Eickhoff, C Mundhenke, N Maass, W Jonat, A Friedl · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: NGAL is a secreted glycoprotein with proposed functions in proliferation and survival. NGAL is expressed in a variety of tumor types including breast carcinomas. This study examines the relationship between NGAL expression in breast carcinomas and established prognostic markers as well as clinical outcome. Methods: Tissue microarrays were constructed from tumor samples from 207 patients with primary invasive breast cancer. Immunhistochemistry was used to evaluate NGAL expression. Primary endpoints were disease-specific survival (DSS) and disease-free survival (DFS). The associations between NGAL expression…