Epistasis between Toll-like receptor (TLR)-9 polymorphisms and variants in IL23R and DLG5 modulates susceptibility to Crohn's disease
HP Török, J Glas, J Konnerth, M Wetzke, P Lohse, T Ochsenkühn, M Folwaczny, B Göke, C Folwaczny, B Müller-Myhsok, S Brand · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: The identification of NOD2 provides important genetic evidence for the role of innate pattern recognition receptors in the pathogenesis of Crohn's disease (CD). Recognition of bacterial DNA via TLR9 seems to be crucial for the maintenance of gut homeostasis and gut inflammation. We previously showed that a promoter polymorphism in TLR9 (-1237 T/C) further increases disease risk in CD patients bearing NOD2 mutations. Here, we tested for genetic interaction of this polymorphism with variants in IL23R, and in other susceptibility genes for CD and analyzed the role of further common TLR9 polymorphisms in the s…
