CareLit Fachartikel
Triple negative breast cancer – molecular basics and clinical impact
C Liedtke · Geburtshilfe und Frauenheilkunde · 2009 · Heft 02
Dokument
1135051
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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zitierfähig
Bibliografische Angaben
Zusammenfassung
Molecular taxonomy of breast cancer Rather than a homogeneous entity, breast cancer is increasingly understood as a heterogeneous mixture of individual subtypes that differ with regard to molecular, pathological and clinical features. Expression of estrogen receptor (ER) and progesterone receptor (PR) as well as HER2 constitute the major determinants of these subtypes and distinguish (a) HER2-positiv, (b) ER-positive/HER2-negative and (c) triple negative breast cancers (TNBC). The latter are characterized by the lack of expression of each of the three receptors. TNBC is highly concordant to the basal-like breast…
Schlagworte
Breast
Association
Dasatinib
Androgen Receptor Antagonists
Cyclophosphamide
Anthracycline
Bevacizumab
Observation
Biomarkers
Dataset
After
Tumor
Geburtshilfe und Frauenheilkunde
