CareLit Fachartikel
Pathophysiology of EGFR and options of targeting
E Stickeler · Geburtshilfe und Frauenheilkunde · 2009 · Heft 02
Dokument
1135052
CareLit-ID
Jahr
2009
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
The family of human epidermal growth factor (HER) receptors representing transmembrane receptor kinases consists of the epidermal growth factor receptor (EGFR; HER-1), HER-2, HER-3 and HER-4, respectively. Several soluble ligands of the epidermal growth factor family induce formation of HER receptor homodimers or heterodimers leading to autophosphorylation of tyrosine residues within the cytoplasmatic catalytic kinase domain of the receptor. Interestingly, HER-2 is the preferred recruited heterodimerization partner despite the fact, that it does not bind to any known ligands of the HER family. In the complex wit…
Schlagworte
Breast
Tumor
Blood-Brain Barrier
Binding Sites
Amphiregulin
Betacellulin
Antibodies
Apoptosis
Cyclin D1
Blood
Geburtshilfe und Frauenheilkunde
