Major Histocompatibility Complex Class I-related Chains A and B (MIC A/B): A Role in the Pathogenesis of Non-alcoholic Steatohepatitis
A Kahraman, S Menziletoglu Yildiz, M Schlattjan, A Kilicarslan, CD Fingas, M Schlensak, H Baba, I Wedemeyer, G Gerken, A Canbay · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatocellular apoptosis is a key mechanism of liver injury in the pathogenesis of non-alcoholic steatohepatitis (NASH). Recently, soluble forms of major histocompatibility complex (MHC) class I-related chains A and B (MIC A/B) were reported to be increased in the sera of patients with chronic liver disease and hepatocellular malignancy. However, the role of MIC A and B in the pathogenesis of NASH has not been explored. We thus aimed to investigate the impact of these stress-induced ligands on liver injury, apoptosis and hepatic fibrosis in patients with NASH. Methodology: Blood and liver tissue were obtained fr…
