CareLit Fachartikel
TGF-β1 initiates signaling from the plasma membrane in hepatocytes
C Meyer, P Godoy, A Bachmann, A Müller, C Stump, I Ilkavets, S Dooley · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1135121
CareLit-ID
Jahr
2009
Publikation
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Metadaten
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Zusammenfassung
The role of endocytosis in TGF-β1 signaling is controversially discussed. Two TGF-β-receptor internalization routes have been proposed. A clathrin mediated uptake resulting in Smad phosphorylation, translocation to the nucleus and transcriptional activity. Via this route, receptors can be recycled back to the cell surface in a Rab11 dependent manner, whereas the caveolin dependent internalization leads to TGF-β1 signal termination and receptor degradation. The initial event in TGF-β-receptor mediated signaling, phosphorylation of Smad2 and 3 has been shown to require endocytosis into early endosomes in various c…
Schlagworte
Endocytosis
TGF-beta
TGF-beta receptor
hepatocyte
dynamin
caveolin
Clathrin
Zeitschrift für Gastroenterologie
