CareLit Fachartikel
The regulation of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 by 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) is altered by a functional promoter variant
U Ehmer, S Kalthoff, T Erichsen, N Freiberg, MP Manns, CP Strassburg · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1135124
CareLit-ID
Jahr
2009
Publikation
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Zusammenfassung
Introduction: The UGT-Glucuronosyltransferase (UGT) 1A7 plays an important role in the metabolism of endogenous and xenobiotic substrates, which include environmental carcinogens and drugs such as the chemotherapeutic compound irinotecan. Low activity alleles of UGT1A7 characterized by variations within the coding and non-coding sequence are associated with cancer predisposition and drug toxicity. The transcriptional regulation of this gene by xenobiotics and a putative influence of SNP variants not completely characterized. Aim of this study was therefore to analyze the regulation of UGT1A7 via TCDD and to eluc…
Schlagworte
AhR
TCDD
UDP-Glucuronosyltransferasen
UGT1A7
Alleles
Population
Zeitschrift für Gastroenterologie
