Towards unravelling the role of the lipid droplet-associated proteins perilipin, adipophilin, and TIP47 in hepatocellular carcinoma
BK Straub, S Singer, J Lehmann-Koch, H Heid, E Specht, R Zimbelmann, K Breuhahn, P Schirmacher · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Lipid droplets (LDs) are present in at least some cells in about two thirds, and are abundant in about 10% of hepatocellular carcinoma (HCC). HCC are therefore one of the rare carcinomas with prominent fatty change. Nevertheless, the significance of LD accumulation in HCC has not been well studied. Amphiphilic proteins of the PAT family of LD-associated proteins, named after their constitutents perilipin, adipophilin, and TIP47, are fundamental for the stabilization of LDs in the cytoplasm of cells. Whereas adipophilin, and TIP47 are nearly ubiquitously expressed, perilipin was thought to be restricted to adipoc…
