CareLit Fachartikel

First characterization of small hepatocytes from human liver as possible source in liver regeneration

D Knobeloch, P Kupczyk, A Lehmann, M Glanemann, N Liu, S Ehnert, A Nüssler · Zeitschrift für Gastroenterologie · 2009 · Heft 01

Dokument
1135130
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
D Knobeloch, P Kupczyk, A Lehmann, M Glanemann, N Liu, S Ehnert, A Nüssler
Ausgabe
Heft 01 / 2009
Seiten
–
Erschienen: 2009-01-20 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1191878

Zusammenfassung

Severe hepatic dysfunction in humans is caused by various diseases such as persistent hepatitis, cirrhosis or liver tumours. Currently, the absence of donors leads to a high mortality rate. Cell based therapies may be a possible alternative to stabilize patients who are waiting for an adequate liver. However, one limitation of cell-based therapies is the availability of functional human hepatocytes. So far, only limited approaches exist to stimulate the proliferation of functional human hepatocytes in vitro, using cytokines which are known to play a key role in liver regeneration. Besides several methods to over…

Schlagworte

Liver regeneration Small hepatocytes cell based therapy Cytokines Hepatitis Tumor Zeitschrift für Gastroenterologie