CareLit Fachartikel
VSV virotherapy of tumors enhances chemotherapeutic efficacy by proteasomal degradation of MCL-1
P Schache, N Strüver, E Gürlevik, MP Manns, F Kühnel, S Kubicka · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1135132
CareLit-ID
Jahr
2009
Publikation
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Zusammenfassung
Over-expression of myeloid cell leukemia 1 protein (Mcl-1), an anti-apoptotic Bcl-2 family member, contributes to chemotherapy resistance of tumors. The short half-life of Mcl-1 makes it an interesting target for therapeutic agents that negatively interfere with cellular protein biosynthesis such as oncolytic viruses (Wirth et al. 2005). Vesicular stomatitis virus (VSV) has been established as oncolytic virus that efficiently disrupts de novo protein biosynthesis of infected cells on different levels (RNA-polymerases I-III, nuclear mRNA export, CAP-dependent translation). Here, we demonstrate that following VSV…
Schlagworte
Mcl-1
VSV
combination therapy
virochemotherapy
Apoptosis
Tumor
Blood
Zeitschrift für Gastroenterologie
