Hepatitis B-associated Acute Liver Failure: Life-saving Immediate Treatment with Entecavir Inhibits the Replication of Hepatitis B Virus and its Sequelae
A Canbay, I Gawlista, C Jochum, R Gieseler, M Schlattjan, M Kassalik, F Saner, A Paul, G Gerken · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatitis B virus (HBV) remains a major cause of acute liver failure (ALF) necessitating a high rate of emergency liver transplantation. Acute infection is followed by high viral replication rates leading to hepatocyte death and, ultimately, ALF. The objective of treating HBV-induced ALF thus is to eliminate, or significantly suppress, HBV replication. In patients, the guanosine nucleoside analogue, entecavir, has demonstrated superior anti-HBV activity when, for example, compared with lamivudine in chronic HBV infection. Objective: To test whether efficient suppression of viral replication in patients with HBV-…
