The Ras-homologous GTPase Arfrp1 is involved in the regulation of triglyceride storage in mouse and human adipose tissue
A Hommel, D Hesse, M Blüher, T Engel, C Zahn, M Moser, R Kluge, HG Joost, A Schürmann · Diabetologie und Stoffwechsel · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: The GTPasw ADP-ribosylation factor related protein 1 (ARFRP1) is required for the recruitment of ARF-like 1 (ARL1) and its effector golgin-245 to the trans-Golgi. In order to investigate the function of ARFRP1 during fat cell development, Arfrp1 was selectively ablated in adipocytes with the Cre/loxP recombination system. In addition, ARFRP1 expression was determined in human adipose tissue. Results: Fat specific null-mutants (Arfrp1ad-/- mice) were viable and of normal size at birth. They showed marked growth retardation during the first days of life and were lipodystrophic. Arfrp1 does not appear to be r…
