Invitation of inactivation of WT1 in pediatric T-ALL

Background: The identification of genomic aberrations including translocations, deletions, amplifications, duplications, and mutations revealed that T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous disease comprising several biological entities. However, the catalog of all genetic lesions, which contribute to the pathogenesis of T-ALL is far from complete. Patients: 102 diagnostic and 12 matched relapse bone marrow samples were investigated. Methods: To delineate novel genetic alterations BAC tiling path array CGH, FISH, and mutation screening were employed. Results: In 5 patients a monoallelic del…