Prognostic role and functional analyses of miRNA expression in neuroblastoma
S Schlierf, P Mestdagh, T Thor, K DePreter, M Baumann, A Eggert, J Vandesompele, A Schramm, JH Schulte · Klinische Pädiatrie · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
MicroRNAs (miRNA) are a recently discovered class of short RNAs that repress translation and promote mRNA degradation by sequence-specific interaction with mRNA. Deregulation of miRNAs has been observed in various malignancies. We here analysed the expression of 430 miRNAs in 62 neuroblastomas using high-throughput real-time PCR. We identified miRNA profiles correlating with survival, MYCN amplification or chromosomal aberrations. MiR-181 and miRNAs of the miR17–92 cluster were highly expressed in neuroblastomas of patients with adverse outcome. The latter miRNAs also correlated with MYCN- amplification and were…
