Liquorbiomarker bei der kortikalen posterioren Atrophie

Objective: To measure CSF concentrations of Aβ1–42, T-Tau and P-Tau181 in patients with posterior cortical atrophy (PCA), a mostly presenile dementia likely to represent a variant of Alzheimer's disease. Design/Methods: CSF samples from 9 cases were analyzed using commercially-available ELISA kits. 14 cognitively healthy individuals and 11 matched patients with typical presentation of Alzheimer's disease (AD) served as controls. Results: The CSF-Aβ1–42 levels in PCA, AD and controls were 415.5 (±163.2), 463.4 (±185.9) and 840.2 (±214.8), respectively. The concentrations of CSF-Tau in PCA, AD and controls were 59…