ABCC1: a gateway for drugs to the ischaemic brain
E Kilic, A Spudich, Ü Kilic, KM Rentsch, R Vig, CM Matter, H Wunderli-Allenspach, JM Fritschy, CL Bassetti, DM Hermann · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
ATP-binding cassette (ABC) transporters are ATP-dependent flippases located at the blood brain barrier (BBB) that are involved in the elimination of drugs from the brain. While the majority of transporters are expressed on the luminal surface of the endothelium, carrying drugs from the brain back into the blood against concentration gradients1, some transporters, including ABCC1 (previously multidrug resistance-associated protein-1), predominantly exhibit abluminal localization on vascular endothelium. Until now, the function of these abluminal transporters remained largely unclear. To elucidate the implication…
