Functional role of ipsilateral motor areas in a simple reaction task in multiple sclerosis

Background: Multiple sclerosis (MS) is a chronic neurological disease that is characterized by both demyelination and axonal injury within the central nervous system (CNS). Neuroplastic changes appear to play a role in functional compensation of brain lesions. These may involve reorganisation of cortical representations on a large anatomical scale. We studied the role of 2 ipsilateral motor areas on performance of a simple reaction time (SRT) task in patients with MS and matched controls using a virtual lesion approach. Moreover, we assessed the relationship between SRT changes following virtual lesion induction…