CareLit Fachartikel
Metaheps exhibit CYP P450 metabolism – induction by ethanol, phenytoin and dexamethasone
A Benesic, NL Rahm, S Ernst, E De Toni, M Escobar, V Gülberg, AL Gerbes · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Dokument
1135980
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Considerable effort is aimed at the search for hepatocyte-like cells to use them in cell based therapies. Transformed peripheral monocytes have been described as a possible source of hepatocyte-like cells. In contrast to primary hepatocytes, monocytes are easy to isolate and available. Since primary hepatocytes loose functional CYP P450-metabolism after few days in culture, hepatocytoid cells with a stable and functional CYP P450 metabolism could markedly improve in vitro toxicology studies and decrease the need for animal testing. Aim of the study: Investigation of drug metabolism in monocyte derived hepa…
Schlagworte
Dexamethasone
After
Acetylcysteine
Acetaminophen
Lead
Zeitschrift für Gastroenterologie
