CareLit Fachartikel

Exclusion of the functional FAS promoter polymorphism -670A>G as a relevant factor for the development of advanced fibrosis or cirrhosis in patients with chronic liver disease

F Grünhage, M Krawczyk, R Goebel, T Sauerbruch, F Lammert · Zeitschrift für Gastroenterologie · 2009 · Heft 09

Dokument
1135984
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
F Grünhage, M Krawczyk, R Goebel, T Sauerbruch, F Lammert
Ausgabe
Heft 09 / 2009
Seiten
–
Erschienen: 2009-09-28 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1241398

Zusammenfassung

Introduction: Recently a polymorphism in the tumor necrosis factor receptor superfamily 6 (FAS) gene has been associated with susceptibility to autoimmune hepatitis (Hiraide et al. Am J Gastroenterol 2005;100:1322–9) and advanced fibrosis (Agarwal et al Tissue Antigens 2007;69:227–35). We aimed to verify this association in a cohort of patients with chronic liver diseases. Patients and methods: Overall, we enrolled 790 patients with chronic liver diseases of mixed aetiologies, including a subset of 60 patients with autoimmune associated liver diseases (AIH, PBC and PBC). Liver fibrosis stages were determined by…

Schlagworte

Association Antigens Ascites Autoimmune Hepatitis Hepatitis Tumor Zeitschrift für Gastroenterologie