Regulation and gene expression of chemokines and adhesion molecules in rat liver after gamma-irradiation

Radiation Induced Liver Diseases (RILD) is a serious clinical complication. CXC and CC chemokines are known to attract inflammatory cells and adhesion molecules play a role in transmigration process to the site of inflammation. Aim of study was to investigate gene expression of CXC, CC-chemokines and their receptor in relation to two adhesion molecules in rat liver after single dose gamma-irradiation. Macrophage inflammatory protein-2 (MIP-2) concentration in serum was measured by ELISA after exposing the rat liver to gamma-irradiation (25Gy). Livers of irradiated animals and of controls (sham-irradiated) were i…