CareLit Fachartikel
Expression of E-selectin and its ligand ESL–1 in rat hepatic stellate cells (HSC): implications for leukocyte extravasation and liver metastasis
M Antoine, CG Tag, AM Gressner, R Müller, P Kiefer · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Dokument
1136497
CareLit-ID
Jahr
2007
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Zusammenfassung
HSC are pericytes of liver sinusoidal endothelial cells. Activation of HSC seems to be involved in repair of liver tissue injury, in liver regeneration and in angiogenesis of liver metastases. Entry of leukocytes but also of tumor cells is controlled by cell adhesion events in particular between the invading cells and endothelial cells. The cytokine-inducible E-selectin mediates binding of neutrophiles to endothelial cells and is implicated in colon cancer metastasis. Binding to E-selectin depends on the presence of sialylated and fucosylated carbohydrate structures which are generated by a(1,3)-fucosyltransfera…
Schlagworte
E-Selectin
ESL-1
HSC
Tumor
Atmosphere
Cytokine
Zeitschrift für Gastroenterologie
