CareLit Fachartikel

Functional analysis of IGFBP–2 overexpression in mouse liver myofibroblats: implications for liver fibrogenesis

R Pannem, A Hoeflich, E Wolf, G Ramadori, JG Scharf · Zeitschrift für Gastroenterologie · 2007 · Heft 01

Dokument
1136499
CareLit-ID
Jahr
2007
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Pannem, A Hoeflich, E Wolf, G Ramadori, JG Scharf
Ausgabe
Heft 01 / 2007
Seiten
–
Erschienen: 2007-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-967778

Zusammenfassung

Liver fibrosis results from excessive accumulation of extracellular matrix (ECM). Different liver cell populations are involved in this process: activated hepatic stellate cells as well as portal and perivascular liver myofibroblasts (LMFs) which represent morphologically and functionally different fibroblast populations. To examine the relationship between IGFBP–2 overexpression and cellular functions of LMFs, LMFs were isolated from wild type (wt) and IGFBP–2 transgenic (BP–2 (±)) mice. Methods: LMFs were obtained by outgrowth from primary hepatocytes isolated from wt or CMV-IGFBP–2 transgenic mice. Expression…

Schlagworte

Igfbp Expression Igf-I Liver Different Overexpression Igf-Ir Protein Synthesis Collagen Fibulin Whereas Zeitschrift für Gastroenterologie