CareLit Fachartikel
Endoglin and its involvement in transdifferentiation of hepatic stellate cells
WN Vreden, SK Meurer, R Weiskirchen, AM Gressner · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Dokument
1136500
CareLit-ID
Jahr
2007
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Zusammenfassung
Aims: Endoglin, a transmembrane accessory receptor for TGF-beta was recently found to be highly expressed on the surface of hepatic stellate cells. Up to now endoglin was mainly known as a TGF-beta receptor on endothelial cells, in which mutations causes the vascular disorder, hereditary haemorrhagic telangiectasia (HHT1). In the current study we tried to evaluate the role of endoglin in liver fibrosis modulating the classical TGF-beta pathway, which is mainly responsible for an increased extracellular matrix protein (ECM) synthesis during liver fibrosis. Methods: The expression of Endoglin in rat hepatic stella…
Schlagworte
Endoglin
Fibrosis
Hepatic stellate cells
siRNA
Antibodies
After
Actin
Zeitschrift für Gastroenterologie
