CareLit Fachartikel

Lithogenic dyslipidemia and ABCG5/ABCG8 gene polymorphisms: a study in 121 siblings with gallstones

F Grünhage, S Tirziu, A Ciocan, S Bel, H Keppeler, F Lammert, M Acalovski · Zeitschrift für Gastroenterologie · 2007 · Heft 01

Dokument
1136502
CareLit-ID
Jahr
2007
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
F Grünhage, S Tirziu, A Ciocan, S Bel, H Keppeler, F Lammert, M Acalovski
Ausgabe
Heft 01 / 2007
Seiten
–
Erschienen: 2007-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-967808

Zusammenfassung

Background Most epidemiological surveys confirm the association of low HDL-cholesterol levels and hypertriglyceridemia with cholesterol gallstone disease. The recently identified hepatobiliary cholesterol transporter is a heterodimeric complex of two proteins which are encoded by the ABCG5 and ABCG8 genes. As recently shown, common genetic variants in this cholesterol transporter account for the variability of plasma cholesterol levels in a reference population (Berge et al. 2002. J Lipid Research; 43: 486–494). Hence both genes represent candidate genes for cholesterol gallstone formation. The present study aim…

Schlagworte

Cholesterol Association Alleles Allele Population Zeitschrift für Gastroenterologie