GBV-C co-infection in HIV patients downregulates CCR5 and CXCR4 surface expression on CD4 cells
C Schwarze-Zander, M Neibecker, S Othman, M Schulz, E Voigt, M Vogel, JC Wasmuth, JK Rockstroh, U Spengler · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: The flavivirus GB virus-C (GBV-C), thus far not known to cause any disease, has been shown to be associated with delayed progression of HIV disease. Recently, in vitro studies demonstrated down-regulation of CCR5 as a potential mechanism of GBV-C to modulate HIV disease progression. We therefore studied surface expression of the two major HIV co-receptors, CCR5 and CXCR4, on CD4+ and CD8+ T-cells in 110 HIV patients stratified with respect to their GBV-C status and immune function. Methods: GBV-C infection was studied in 110 HIV patients by RT-PCR. CCR5Δ32 mutation was analyzed by real time PCR. FACS analy…
