CareLit Fachartikel
Should treatment of hepatitis B depend on HBV genotypes?
J Wiegand, D Hasenclever, HL Tillmann · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Dokument
1136510
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Jahr
2007
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Zusammenfassung
Objective Standard treatment for hepatitis B is either based on interferon or on nucleos(t)ide analogues. We summarize available evidence on treatment outcome by HBV-genotype and investigate whether there is a role for genotypes in selecting treatment. Methods PubMed, EASL- and AASLD-abstracts were screened for publications reporting treatment results (HBeAg seroconversion, loss of HBeAg) broken down by genotype. 18 reports with at least 30 patients were included. Forest-plot techniques were applied to visualise association of HBV-genotypes (A vs. D, B vs. C) with treatment outcome given by type of treatment. Th…
Schlagworte
adefovir
entecavir
genotype
hepatitis B
interferon
lamivudine
treatment
Treatment Outcome
Hepatitis
Association
Abstracts
Zeitschrift für Gastroenterologie
