α-Lipoic acid induces apoptosis in hepatoma cells
A Columbano, G Simbula, GM Ledda-Columbano, L Sanna, M Deidda, A Diana, M Pibiri · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
α-lipoic acid (α-LA) is an antioxidant used for the treatment of a variety of diseases, including liver cirrhosis, heavy metal poisoining, and diabetic polyneuropathy. In addition to its protective effect against oxidative stress, α-LA induces apoptosis in different cancer cells types. However, whether α-LA acid induces apoptosis of hepatoma cells is unknown. Herein, we investigated whether α-LA induces apoptosis in two different hepatoma cell lines FaO and HepG2. The results showed that α-LA inhibits the growth of both cell lines as indicated by the reduction in cell number, the reduced expression of cyclin A a…
