Treatment of Hep G2 Cells with Adiponectin Attenuates Fas Expression and Apoptosis
G Marquitan, L Bechmann, A Katsounas, M Schlattjan, M Odenthal, G Gerken, A Canbay · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Fas expression with increased Fas-mediated apoptosis and liver injury are prominent features of fatty liver diseases (NAFLD/ALFD). In contrast, adiponectin is believed to be hepatoprotective. Earlier data of ours suggested that hepatocyte apoptosis plays an important role in liver injury, inflammation, and fibrosis. Based on this concept, our Aim was to ascertain whether adiponectin attenuates long-chain free fatty acid (FFA)-induced Fas expression and, therefore, hepatocyte apoptosis. Methods: Hep G2 cells were cultured for 48h in the presence of 1 mM FFAs (2: 1 oleate: palmitate) and treated with or with…
