CareLit Fachartikel
Insulin resistance in liver cirrhosis is not associated with circulating Retinol Binding Protein 4
E Yagmur, R Weiskirchen, AM Gressner, C Trautwein, F Tacke · Zeitschrift für Gastroenterologie · 2007 · Heft 01
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1136513
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Jahr
2007
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Zusammenfassung
Background/Aims: Retinol Binding Protein 4 (RBP4) has been identified as a novel adipokine mediating systemic insulin resistance, and increased RBP4 expression by adipocytes has been proposed to mediate its pro-diabetogenic effects (Yang et al, Nature 2005; 436: 356). Moreover, elevated serum RBP4 indicated overt or impending insulin resistance in lean, obese and type 2 diabetic subjects (Graham et al, NEJM 2006; 354: 24). As insulin resistance is present in nearly all patients with liver cirrhosis and dysregulation(s) of adipocytokines have been shown in cirrhosis, we evaluated RBP4 in patients with chronic liv…
Schlagworte
RBP4
adiponectin
chronic liver disease
glucose metabolism
liver cirrhosis
resistin
Adipocytes
Adipokines
Adipokine
C-Peptide
Obesity
Zeitschrift für Gastroenterologie
