Der chronische Verlauf der Sarkoidose ist mit einer BTNL2 Genvariante assoziiert

Sarcoidosis is an inflammatory granulomatous disorder that primarily affects lungs and lymph nodes. Recently, a significant association of sarcoidosis with a frequent SNP in the BTNL2 gene, rs2076530, was described in a German sarcoidosis sample. BTNL2 is a member of the immunoglobulin gene family and is related to CD80 and CD86 co-stimulatory receptors, although its exact function is unknown. No replication of the BTNL2 rs2076530 susceptibility to sarcoidosis has yet been done in an independent German case-control study. We therefore performed a case-control association study including 210 patients with sarcoid…