Echtzeit in-vivo Histopathologie zur Detektion von Neoplasien im GI-Trakt mittels einer tragbaren konfokalen Minisonde – Eine verblindete Analyse

Objectives: Confocal fluorescence microscopy (CFM) has been mentioned to be a promising tool for in-vivo examination of the gastrointestinal mucosa. Recently, a prototype of a portable confocal laser scanning microscope with a portable miniprobe (maximum diameter 2.5mm) has been developed. The aim of the present study was to evaluate the potential benefit of this new device for detection of neoplasia in a blinded manner. Methods: A total of 47 patients with known or supected neoplasia in the upper (n=34) or lower GI-tract (n=13) were examined with standard endoscopes. Chromoendoscopy with 2–5ml cresyl violet 0.2…