CareLit Fachartikel
Reduced oxidative stress in hyperglycaemic protein kinase C zeta knock-out mice does not protect against diabetic nephropathy
M Meier, JK Park, J Menne, C Lindschau, M Leitges, H Haller · Diabetologie und Stoffwechsel · 2007 · Heft 08
Dokument
1136851
CareLit-ID
Jahr
2007
Publikation
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Metadaten
DOI
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Zusammenfassung
Hyperglycemia increases reactive oxygen species (ROS) production e.g. with subsequent activation of the Protein kinase C (PKC) signalling pathway. It has been postulated that a positive feedback loop may occur between ROS and the activation of PKC-ζ as in the diabetic state the PKC-ζ (PKC-ζ) isoform is required for ROS generation from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in mesangial cells exposed to high glucose condition. Furthermore, the requirement of PKC-zeta for F-actin disassembly may involve ROS. Therefore, deletion of PKC-ζ in vivo should result in prevention of experimental diabe…
Schlagworte
After
Reactive Oxygen Species
Albuminuria
Creatinine
Adenine
Actin
Diabetologie und Stoffwechsel
