Common NOD2/CARD15 variants are not associated with susceptibility or clinicopathologic characteristics of sporadic colorectal cancer in Hungarian patients
O Gemela, E Hitre, F Szalay, K Zinober, P Fuszek, H Horvath, L Lakatos, S Fischer, J Osztovits, J Papp, P Ferenci, PL Lakatos · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: Epidemiological observations suggest that cancer arises from chronically inflamed tissues. Inflammatory bowel disease (IBD) is a typical example as patients with longstanding IBD are at an increased risk for developing colorectal cancer (CRC) and mutations of the NOD2/CARD15 gene increase the risk for Crohn's disease (CD). Recently, NOD2/CARD15 has been associated with a risk for CRC in some studies, which stemmed from ethnically diverse populations. Our aim was to identify common NOD2/CARD15 mutations in Hungarian patients with sporadic CRC. Methods: A total of 194 sporadic CRC patients (m/f: 108/86, age…
