CareLit Fachartikel
Drug induced liver injury. A review
A Pár · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Dokument
1136898
CareLit-ID
Jahr
2007
Publikation
PDF
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Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
A brief overview is devoted to summarize the pathogenesis of drug induced hepatotoxicity, the common adverse drug reactions that involve the liver. The main types of these abnormalities are idiosyncratic – metabolic and immunologic – as well as direct toxic reactions, all of which are determined by genetic and environmental factors. Idiosyncratic reactions are characterized by a variable delay or latency period, ranging from 5–90 days from the initial ingestion of the drug, and are not dose-dependent, but may even be fatal if the drug is continued once the reaction has begun. Other drugs, such as acetaminophen e…
Schlagworte
Acetaminophen
Cholestasis
Diagnosis
Affect
Hepatitis
Zeitschrift für Gastroenterologie
