Significant impact of the presence of type 2 diabetes on the cardiovascular risk conferred by the plasminogen activator inhibitor-1–675 5G/4G polymorphism

Background/Aims: The -675 5G/4G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene has been associated with increased plasma levels of PAI-1 and, in some studies, with increased vascular risk. Hardly any data on the vascular risk conferred by this polymorphism are available for patients with type 2 diabetes (T2DM). We therefore aimed at investigating i) the association of this polymorphism with angiographiaclly diagnosed coronary artery disease (CAD) and ii) its impact on future vascular events in patients with T2DM and in nondiabetic individuals. Methods: Genotyping was performed in 672 consecut…