Promoter hypermethylation and aberrant expression of EMP3at 19q13.3 in oligodendrogliomas and astrocytomas

Allelic losses on the long arm of chromosome 19 are found in the majority of oligodendroglial tumors and approximately 20–50% of astrocytic tumors. Losses on 19q are one of the earliest events in oligodendrogliomas, whereas such losses are linked to progression in astrocytomas. Due to a t(1;19) (q10;p10) translocations oligodendrogliomas show a loss of the entire long arm of chromosome 19, whereas astrocytomas exhibit interstitial and telomeric deletions without translocations. However, altered tumor suppressor genes (TSG) on 19q are still elusive in gliomas. We used cDNA microarray expression profiling to ident…