Neuropathology of conditional models of Parkinson's disease
S Nuber, E Petrasch-Parwez, B Winner, J Winkler, S von Hörsten, T Schmidt, J Boy, HP Ngyuen, M Kuhn, P Teismann, JB Schulz, M Neumann, BJ Pichler, G Reischl, C Holzmann, I Schmitt, A Bornemann, W Kuhn, F Zimmermann, A Servadio, O Rieß · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Alpha-synuclein has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease. This disorder is based on progressive neuropathological alterations leading to motor abnormalities that are frequently predated by olfactory dysfunction and often accompanied by cognitive decline in later stages of the disease. Whether the neurodegenerative process might be halted or even reversed is presently unknown. In order to explore whether alpha-synuclein induces these alterations we generated conditional mouse models by using the tet-regulatable system. Mice expressing high levels o…
