Induction of prostaglandin E2 receptor 3 (EP3) in SK-N-SH-cells by IL-1 beta: involvement of p38-MAPK and NFkappaB

IL-1beta and PGE2 are found to be increased in several neuro-inflammatory and degenerative processes in the brain, such as cerebral ischemia (CI), traumatic brain injuries or Alzeimer's disease (AD). PGE2 exerts its several effects by binding to four different G-protein-coupled receptors named EP1-EP4. Stimulation with the pro-inflammatory cytokine IL-1beta produces a marked up-regulation of EP3 synthesis in the human neuroblastoma cell line SK-N-SH (p